[Effect of dietary mineral nutrients and vitamins on metabolism of rat fed with high fat]

Author: Jiang L, Sun C, Zhou X, Wang H, Ren L

Author affiliation: Public Health College, Harbin Medical University, Harbin 150001, China.

Publication date & source: 2004.07, Wei Sheng Yan Jiu., 33(4):447-9.

Publication type: English Abstract; Research Support, Non-U.S. Gov't

OBJECTIVE: To explore dietary mineral nutrients (calcium, magnesium, zinc, ferric, chromium) and vitamins (vitamin A, B1, B2, C, D, E) on the effect of metabolic disorder of Wistar rat fed with high fat diet. METHODS: Fifty obesity-prone male rats were randomly divided into 5 groups: A group were fed with basic diet, B group were fed with high fat diet and normal minerals and vitamins, C group were fed with high fat diet with lower minerals and vitamins, D group were fed with high fat diet with higher minerals and vitamins, E group were fed with high fat diet with only higher calcium. After 8 weeks, blood glucose, serum insulin and leptin, serum triglycerides, cholesterol and high-density lipoprotein were measured respectively. RESULTS: The body weight and fat content in B group were significantly higher than those of other groups. The body weight in D, E group decreased significantly compared with B group, both of which are similar with A group. In the case of blood glucose, serum insulin, leptin,triglycerides, cholesterol and high-density lipoprotein, they all have the tendency of decreasing in D group compared with E group. CONCLUSION: In addition to reducing body weight and fat content, dietary mineral nutrients and vitamins can also ameliorate the blood glucose and improve hyperinsulinemia and hyperleptinemia, modify the metabolic disordor of rat fed with high fat diet.