New findings from the Bipolar Collaborative Network: clinical implications for therapeutics.

Author: Post RM, Altshuler LL, Frye MA, Suppes T, McElroy S, Keck PE Jr, Leverich GS, Kupka R, Nolen WA, Grunze H

Author affiliation: Penn State College of Medicine, Hershey, PA, USA. robert.post@speakeasy.net

Publication date & source: 2006.12, Curr Psychiatry Rep., 8(6):489-97.

Publication type: Research Support, Non-U.S. Gov't; Review

In this article, we highlight recent Bipolar Collaborative Network data. We found that childhood-onset bipolar illness is common, often goes untreated for more than a decade, and carries a poor prognosis. During randomized studies of adjunctive medications in depression: 1) Venlafaxine showed higher switch rates than bupropion or sertraline; 2) Tranylcypromine was as well tolerated as lamotrigine; and 3) Modafinil was more effective than placebo. Finally, in treatment of overweight and obesity, topiramate and sibutramine showed equal efficacy but poor tolerability, and zonisamide data showed that it may be useful for mood and weight loss.