Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series.

Author: Roy Chengappa KN, Levine J, Rathore D, Parepally H, Atzert R

Author affiliation: Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O'Hara Street, Pittsburgh, PA 15213-2593, USA. chengappakn@msx.upmc.edu

Publication date & source: 2001.04, Eur Psychiatry., 16(3):186-90.

Publication type: Case Reports

Topiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.