Creatine in Treating Patients With Cancer-Associated Weight Loss

Information provided by National Cancer Institute (NCI)
Information obtained from ClinicalTrials.gov on 2006-12-08
Link to the current ClinicalTrials.gov record.

Condition(s) treated: Anorexia; Cachexia; Unspecified Adult Solid Tumor, Protocol Specific; Weight Changes

Intervention: creatine (Drug); biologically based therapies (Procedure); cancer prevention intervention (Procedure); complementary and alternative therapy (Procedure); nutritional supplementation (Procedure); nutritional support (Procedure); supportive care/therapy (Procedure)

Phase: Phase 3

Enrollment status: Recruiting. Expecting to enroll 274 people.

Sponsor: North Central Cancer Treatment Group

Principal investigator(s) or official(s):
Aminah Jatoi, MD, Study Chair, Affiliation: Mayo Clinic
Charles L. Loprinzi, MD, Affiliation: Mayo Clinic

Summary

RATIONALE: It is not yet known whether the supplement creatine is effective in increasing weight and improving appetite and quality of life in patients who have cancer.

PURPOSE: This randomized phase III trial is studying how well creatine works in increasing weight and improving appetite and quality of life in patients with weight loss caused by cancer.

Clinical Details

Official title: Phase III Double-Blind, Placebo-Controlled Randomized Comparison of Creatine for Cancer-Associated Weight Loss

Study design: Interventional, Supportive Care, Randomized, Double-Blind, Placebo Control

Detailed description: OBJECTIVES:

- Compare weight-gain effects of creatine vs placebo in patients with cancer-associated weight loss and/or anorexia.

- Determine the effect of these regimens on quality of life in these patients.

- Compare the toxic effects of these regimens in these patients.

- Compare survival rates of patients treated with these regimens.

OUTLINE: This is a randomized, double-blind, placebo-controlled study. Patients are stratified according to primary cancer type (lung vs gastrointestinal vs other), weight loss severity (< 10 lbs vs ≥10 lbs), age (< 50 years vs ≥ 50 years), planned concurrent chemotherapy (yes vs no), gender, and prognosis. Patients are randomized to 1 of 2 treatment arms.

- Arm I: Patients receive oral creatine daily.

- Arm II: Patients receive oral placebo daily. In both arms, treatment continues in the absence of unacceptable toxicity as long as treatment is considered beneficial.

Patients are followed every 6 months for up to 5 years.

PROJECTED ACCRUAL: A total of 274 patients (137 per arm) will be accrued for this study within approximately 19 months.

Eligibility

Minimum eligible age: 18 Years. Eligible gender(s): Both.

Criteria:

DISEASE CHARACTERISTICS:
- Histologically or cytologically confirmed cancer other than primary brain cancer

- Considered incurable with available therapies

- History of weight loss ≥ 5 lbs in 2 months or fewer AND/OR estimated intake of < 20 cal/kg daily

- Determination by attending physician that weight gain would benefit patient

- Perception by patient that weight loss is a problem

- No symptomatic or untreated brain metastases

- No clinical evidence of ascites
PATIENT CHARACTERISTICS:
Age
- 18 and over
Performance status
- ECOG 0-2
Life expectancy
- At least 3 months
Hematopoietic
- Not specified
Hepatic
- Not specified
Renal
- Creatinine normal
Cardiovascular
- No poorly controlled congestive heart failure

- No poorly controlled hypertension
Other
- Able to reliably receive oral medication

- Must be alert and mentally competent

- No known obstruction of the alimentary tract, malabsorption, or intractable vomiting

- No diabetes that is controlled by insulin

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Concurrent chemotherapy allowed
Endocrine therapy
- No other concurrent adrenal corticosteroids, androgens, or progestational agents within 30 days after study entry

- Concurrent short-term dexamethasone for chemotherapy-associated emesis is allowed

- Concurrent inhalant, topical, or optical steroids allowed
Radiotherapy
- No concurrent radiotherapy to the bowel or stomach

- Other concurrent radiotherapy allowed
Surgery
- Not specified
Other
- No prior creatine use

- No concurrent tube feedings or parenteral nutrition

Locations and Contact Information

Mobile Infirmary Medical Center, Mobile, Alabama 36652-2144, United States; Recruiting
Clinical Trials Office - Mobile Infirmary Medical Center, Phone: 251-435-3942
Mayo Clinic Scottsdale, Scottsdale, Arizona 85259-5499, United States; Recruiting
Clinical Trials Office - Mayo Clinic Scottsdale, Phone: 507-538-7623, Email: cancerclinicaltrials@mayo.edu
Aurora Presbyterian Hospital, Aurora, Colorado 80012, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Boulder Community Hospital, Boulder, Colorado 80301-9019, United States; Recruiting
Clinical Trials Office - Boulder Community Hospital, Phone: 303-938-5253
CCOP - Colorado Cancer Research Program, Incorporated, Denver, Colorado 80224-2522, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Hope Cancer Care Center at Longmont United Hospital, Longmont, Colorado 80502, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
North Suburban Medical Center, Thornton, Colorado 80229, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Penrose Cancer Center at Penrose Hospital, Colorado Springs, Colorado 80933, United States; Recruiting
Clinical Trials Office - Penrose Cancer Center, Phone: 719-776-5275
Porter Adventist Hospital, Denver, Colorado 80210, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Presbyterian - St. Luke's Medical Center, Denver, Colorado 80218, United States; Recruiting
Clinical Trials Office - Presbyterian - St. Luke's Medical Cen, Phone: 303-839-6821
Rose Medical Center, Denver, Colorado 80220, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Sky Ridge Medical Center, Lone Tree, Colorado 80124, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
St. Joseph Hospital, Denver, Colorado 80218, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
St. Mary-Corwin Regional Medical Center, Pueblo, Colorado 81004, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction, Colorado 81502, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Swedish Medical Center, Englewood, Colorado 80110, United States; Recruiting
Eduardo R. Pajon, MD, Phone: 303-777-2663
Mayo Clinic - Jacksonville, Jacksonville, Florida 32224, United States; Recruiting
Clinical Trials Office - Mayo Clinic - Jacksonville, Phone: 507-538-7623, Email: cancerclinicaltrials@mayo.edu
MBCCOP - Medical College of Georgia Cancer Center, Augusta, Georgia 30912, United States; Recruiting
Randall F. Roberts, Phone: 706-721-6878
Tripler Army Medical Center, Honolulu, Hawaii 96859, United States; Recruiting
Jeffrey L. Berenberg, MD, Phone: 808-433-4089
BroMenn Regional Medical Center, Normal, Illinois 61761, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Cancer Treatment Center at Pekin Hospital, Pekin, Illinois 61554, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Carle Cancer Center at Carle Foundation Hospital, Urbana, Illinois 61801, United States; Recruiting
Clinical Trials Office - Carle Cancer Center, Phone: 800-446-5532
CCOP - Carle Cancer Center, Urbana, Illinois 61801, United States; Recruiting
Clinical Trials Office - CCOP - Carle Cancer Center, Phone: 800-446-5532
CCOP - Illinois Oncology Research Association, Peoria, Illinois 61615, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Community Cancer Center, Normal, Illinois 61761, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Community Hospital of Ottawa, Ottawa, Illinois 61350, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Eureka Community Hospital, Eureka, Illinois 61530, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Galesburg Clinic, Galesburg, Illinois 61401, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Galesburg Cottage Hospital, Galesburg, Illinois 61401, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Moline, Illinois 61265, United States; Recruiting
Stewart C. Garneau, MD, Phone: 309-779-4800
Graham Hospital, Canton, Illinois 61520, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Hopedale Medical Complex, Hopedale, Illinois 61747, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Illinois Valley Community Hospital, Peru, Illinois 61354, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Joliet Oncology-Hematology Associates, Limited - West, Joliet, Illinois 60435, United States; Recruiting
Kendrith M. Rowland, MD, Phone: 217-383-3010
Mason District Hospital, Havana, Illinois 62644, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
McDonough District Hospital, Macomb, Illinois 61455, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Memorial Hospital, Carthage, Illinois 62321, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Methodist Medical Center of Illinois, Peoria, Illinois 61636, United States; Recruiting
Clinical Trials Office - Methodist Medical Center of Illinois, Phone: 309-243-3000
Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa, Illinois 61350, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria, Illinois 61615, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
OSF St. Francis Medical Center, Peoria, Illinois 61637, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Perry Memorial Hospital, Princeton, Illinois 61356, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Proctor Hospital, Peoria, Illinois 61614, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Rush-Copley Cancer Care Center, Aurora, Illinois 60507, United States; Recruiting
Kendrith M. Rowland, MD, Phone: 217-383-3010
St. Joseph Medical Center, Bloomington, Illinois 61701, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
St. Margaret's Hospital, Spring Valley, Illinois 61362, United States; Recruiting
John W. Kugler, MD, Phone: 309-243-3000
Trinity Medical Center - East, Moline, Illinois 61265, United States; Recruiting
Stewart C. Garneau, MD, Phone: 309-779-4800
Reid Hospital & Health Care Services, Incorporated, Richmond, Indiana 47374, United States; Recruiting
Howard M. Gross, MD, Phone: 765-983-3000
Saint Anthony Memorial Health Centers, Michigan City, Indiana 46360, United States; Recruiting
Kendrith M. Rowland, MD, Phone: 217-383-3010
St. Francis Hospital and Health Centers - Beech Grove Campus, Beech Grove, Indiana 46107, United States; Recruiting
Howard M. Gross, MD, Phone: 317-787-3311
CCOP - Iowa Oncology Research Association, Des Moines, Iowa 50309, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Cedar Rapids Oncology Associates, Cedar Rapids, Iowa 52403, United States; Recruiting
Clinical Trials Office - Cedar Rapids Oncology Associates, Phone: 319-363-2690
Bettendorf, Iowa 52722, United States; Recruiting
Stewart C. Garneau, MD, Phone: 309-779-4800
John Stoddard Cancer Center at Iowa Lutheran Hospital, Des Moines, Iowa 50316-2301, United States; Recruiting
Clinical Trials Office - John Stoddard Cancer Center, Phone: 515-241-8704
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa 50309, United States; Recruiting
Clinical Trials Office - John Stoddard Cancer Center, Phone: 515-241-6727
Medical Oncology and Hematology Associates - West Des Moines, West Des Moines, Iowa 50266, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Medical Oncology and Hematology Associates at John Stoddard Cancer Center, Des Moines, Iowa 50309, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Medical Oncology and Hematology Associates at Mercy Cancer Center, Des Moines, Iowa 50314, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Mercy Cancer Center at Mercy Medical Center - Des Moines, Des Moines, Iowa 50314, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Mercy Cancer Center at Mercy Medical Center - North Iowa, Mason City, Iowa 50401, United States; Recruiting
Clinical Trials Office - Mercy Cancer Center, Phone: 641-422-6304
Mercy Capitol Hospital, Des Moines, Iowa 50307, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Mercy Medical Center - Sioux City, Sioux City, Iowa 51104, United States; Recruiting
Donald B. Wender, MD, PhD, Phone: 712-252-9326
Mercy Regional Cancer Center at Mercy Medical Center, Cedar Rapids, Iowa 52403, United States; Recruiting
Martin Wiesenfeld, MD, Phone: 319-398-6011
Ottumwa Regional Health Center Cancer Center, Ottumwa, Iowa 52501, United States; Recruiting
Roscoe F. Morton, MD, FACP, Phone: 515-244-7586
Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa 51101, United States; Recruiting
Donald B. Wender, MD, PhD, Phone: 712-252-9326
Siouxland Regional Cancer Center, Sioux City, Iowa 51101, United States; Recruiting
Clinical Trials Office - Siouxland Regional Cancer Center, Phone: 712-252-9349
St. Luke's Hospital, Cedar Rapids, Iowa 52402, United States; Recruiting
Martin Wiesenfeld, MD, Phone: 319-369-7211
St. Luke's Regional Medical Center, Sioux City, Iowa 51104, United States; Recruiting
Donald B. Wender, MD, PhD, Phone: 712-252-9326
Associates in Womens Health, PA - North Review, Wichita, Kansas 67203, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Kingman, Kingman, Kansas 67068, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Wichita, Wichita, Kansas 67214, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Chanute, Chanute, Kansas 66720, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Dodge City, Dodge City, Kansas 67801, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - El Dorado, El Dorado, Kansas 67042, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Medical Arts Tower, Wichita, Kansas 67208, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Newton, Newton, Kansas 67114, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Parsons, Parsons, Kansas 67357, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Pratt, Pratt, Kansas 67124, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Salina, Salina, Kansas 67042, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Wellington, Wellington, Kansas 67152, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Cancer Center of Kansas, PA - Winfield, Winfield, Kansas 67156, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
CCOP - Wichita, Wichita, Kansas 67214, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Southwest Medical Center, Liberal, Kansas 67901, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
Via Christi Cancer Center at Via Christi Regional Medical Center, Wichita, Kansas 67214, United States; Recruiting
Shaker R. Dakhil, MD, FACP, Phone: 316-262-4467
CCOP - Ochsner, New Orleans, Louisiana 70121, United States; Recruiting
Carl G. Kardinal, MD, Phone: 504-842-3910
Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans, Louisiana 70121, United States; Recruiting
Carl G. Kardinal, MD, Phone: 504-842-3910
Ochsner Clinic of Baton Rouge, Baton Rouge, Louisiana 708169990, United States; Recruiting
Carl G. Kardinal, MD, Phone: 504-842-3910
Terrebonne General Medical Center, Houma, Louisiana 70360, United States; Recruiting
Carl G. Kardinal, MD, Phone: 504-842-3910
CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan 48106, United States; Recruiting
Philip J. Stella, MD, Phone: 877-590-5995
Community Cancer Center of Monroe, Monroe, Michigan 48162, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Foote Hospital, Jackson, Michigan 49201, United States; Recruiting
Philip J. Stella, MD, Phone: 517-788-4800
Genesys Hurley Cancer Institute, Flint, Michigan 48503, United States; Recruiting
Clinical Trials Office - Genesys Hurley Cancer Institute, Phone: 810-762-8057
Haematology-Oncology Associates of Ohio and Michigan, PC, Lambertville, Michigan 48144, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Hickman Cancer Center at Bixby Medical Center, Adrian, Michigan 49221, United States; Recruiting
Clinical Trials Office - Hickman Cancer Center, Phone: 517-265-0116
Hurley Medical Center, Flint, Michigan 48503, United States; Recruiting
Clinical Trials Office - Hurley Medical Center, Phone: 810-762-8057
Mercy Memorial Hospital System, Monroe, Michigan 48162, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan 48123-2500, United States; Recruiting
Clinical Trials Office - Oakwood Cancer Center, Phone: 313-593-8090
Seton Cancer Institute - Saginaw, Saginaw, Michigan 48601, United States; Recruiting
Oncology Research Center, Phone: 989-776-8411
Sparrow Regional Cancer Center, Lansing, Michigan 48909, United States; Recruiting
Philip J. Stella, MD, Phone: 517-364-2780
St. John Macomb Hospital, Warren, Michigan 48093, United States; Recruiting
Philip J. Stella, MD, Phone: 586-573-5757
St. Joseph Mercy Cancer Center at St. Joseph Mercy Hospital, Ann Arbor, Michigan 48106-0995, United States; Recruiting
Philip J. Stella, MD, Phone: 734-712-5658
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan 48236, United States; Recruiting
Clincial Trials Office - Van Elslander Cancer Center, Phone: 313-343-3166
CCOP - Duluth, Duluth, Minnesota 55805, United States; Recruiting
Daniel Nikcevich, MD, PhD, Phone: 218-786-8364
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota 55416, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
Fairview Ridges Hospital, Burnsville, Minnesota 55337, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
Fairview Southdale Hospital, Edina, Minnesota 55435, United States; Recruiting
Clinical Trials Office - Fairview Southdale Hospital, Phone: 612-625-3650
Hubert H. Humphrey Cancer Center at North Memorial Medical Center, Robbinsdale, Minnesota 55422-2900, United States; Recruiting
Clinical Trials Office - Hubert H. Humphrey Cancer Center, Phone: 763-520-1893
Immanuel St. Joseph's Clinic, Mankato, Minnesota 56002, United States; Recruiting
Glenn S. Harman, MD, Phone: 507-625-4031
Mayo Clinic Cancer Center, Rochester, Minnesota 55905, United States; Recruiting
Clinical Trials Office - Mayo Clinic Cancer Center, Phone: 507-538-7623, Email: cancerclinicaltrials@mayo.edu
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota 55433, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota 55432, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
MeritCare Clinic - Bemidji, Bemidji, Minnesota 56601, United States; Recruiting
Preston D. Steen, MD, Phone: 701-234-2397
Miller-Dwan Medical Center, Duluth, Minnesota 55805, United States; Recruiting
Daniel Nikcevich, MD, PhD, Phone: 218-727-8762
Minnesota Oncology Hematology, PA - Woodbury, Woodbury, Minnesota 55125, United States; Recruiting
Daniel Nikcevich, MD, PhD, Phone: 651-735-7414
Minnesota Oncology Hematology, PA at Maplewood Cancer Center, Maplewood, Minnesota 55109, United States; Recruiting
Daniel Nikcevich, MD, PhD, Phone: 612-779-7978
Park Nicollet Health Services, St. Louis Park, Minnesota 55416, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
Ridgeview Medical Center, Waconia, Minnesota 55387, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
St. Mary's - Duluth Clinic Cancer Center, Duluth, Minnesota 55805, United States; Recruiting
Daniel Nikcevich, MD, PhD, Phone: 218-786-3625
United Hospital, St. Paul, Minnesota 55102, United States; Recruiting
Patrick J. Flynn, MD, Phone: 612-863-8585
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital, Minneapolis, Minnesota 55407, United States; Recruiting
Clinical Trials Office - Virginia Piper Cancer Institute at Ab, Phone: 612-863-5654
Hattiesburg Clinic, PA at Forrest General, Hattiesburg, Mississippi 39401, United States; Recruiting
Carl G. Kardinal, MD, Phone: 504-842-3910
Hematology & Oncology Clinic, Hattiesburg, Mississippi 39402, United States; Recruiting
Carl G. Kardinal, MD, Phone: 504-842-3910
Arch Medical Services, Incorporated at Center for Cancer Care Research, Saint Louis, Missouri 63141, United States; Recruiting
Alan P. Lyss, MD, Phone: 314-628-1210
Missouri Baptist Cancer Center, St. Louis, Missouri 63131, United States; Recruiting
Alan P. Lyss, MD, Phone: 314-996-5569
Big Sky Oncology, Great Falls, Montana 59405, United States; Recruiting
Grant W. Harrer, MD, FACP, CCTI, Phone: 406-455-2820
Bozeman Deaconess Hospital, Bozeman, Montana 59715, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-585-5000
CCOP - Montana Cancer Consortium, Billings, Montana 59101, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-259-2245
Community Medical Center, Missoula, Montana 59801, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-728-4100
Deaconess Billings Clinic - Downtown, Billings, Montana 59107-7000, United States; Recruiting
Clinical Trials Office - Deaconess Billings Clinic - Downtown, Phone: 800-996-2663, Email: research@billingsclinic.org
Glacier Oncology, PLLC, Kalispell, Montana 59901, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-752-7600
Great Falls Clinic, Great Falls, Montana 59405, United States; Recruiting
Thomas A. Warr, MD, Phone: 406-727-4584
Hematology-Oncology Centers of the Northern Rockies - Billings, Billings, Montana 59101, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-238-6290
Kalispell Medical Oncology, Kalispell, Montana 59901, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-752-8900
Kalispell Regional Medical Center, Kalispell, Montana 59901, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-752-5111
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana 59807, United States; Recruiting
Clinical Trials Office - Montana Cancer Center, Phone: 406-329-7029
Montana Cancer Specialists at Montana Cancer Center, Missoula, Montana 59807-7877, United States; Recruiting
Clinical Trials Office - Montana Cancer Specialists, Phone: 406-238-6962
Northern Rockies Radiation Oncology Center, Billings, Montana 59101, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-248-2212
Sletten Regional Cancer Institute at Benefis Healthcare, Great Falls, Montana 59405, United States; Recruiting
Grant W. Harrer, MD, FACP, CCTI, Phone: 406-455-2820
St. James Community Hospital, Butte, Montana 59701, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-782-8361
St. Peter's Hospital, Helena, Montana 59601, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-442-2480
St. Vincent Healthcare, Billings, Montana 59101, United States; Recruiting
Patrick W. Cobb, MD, Phone: 406-657-7000
Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska 68124, United States; Recruiting
Clinical Trials Office - Alegant Health Cancer Center, Phone: 402-572-2765
Cancer Resource Center - Lincoln, Lincoln, Nebraska 68510, United States; Recruiting
Alan R. Berg, MD, Phone: 402-420-7000
CCOP - Missouri Valley Cancer Consortium, Omaha, Nebraska 68106, United States; Recruiting
Gamini S. Soori, MD, FACP, FRCP, MBA, Phone: 402-393-3110
Creighton University Medical Center, Omaha, Nebraska 68131-2197, United States; Recruiting
Clinical Trials Office - Creighton University Medical Center, Phone: 402-280-5009
Immanuel Medical Center, Omaha, Nebraska 68122, United States; Recruiting
Gamini S. Soori, MD, FACP, FRCP, MBA, Phone: 402-393-3110
Rutherford Hospital, Rutherfordton, North Carolina 28139, United States; Recruiting
James D. Bearden, MD, Phone: 864-560-6812
Bismarck Cancer Center, Bismarck, North Dakota 58501, United States; Recruiting
Edward J. Wos, DO, Phone: 701-323-5741
Cancer Care Center at Medcenter One Hospital, Bismarck, North Dakota 58501, United States; Recruiting
Edward J. Wos, DO, Phone: 701-323-5741
CCOP - MeritCare Hospital, Fargo, North Dakota 58122, United States; Recruiting
Preston D. Steen, MD, Phone: 701-234-2397
MeritCare Medical Group, Fargo, North Dakota 58122, United States; Recruiting
Preston D. Steen, MD, Phone: 701-234-2397
Mid Dakota Clinic, PC, Bismarck, North Dakota 58501, United States; Recruiting
Clinical Trials Office - Mid Dakota Clinic, PC, Phone: 701-530-6950
St. Alexius Medical Center, Bismarck, North Dakota 58502, United States; Recruiting
Clinical Trials Office - St. Alexius Medical Center, Phone: 701-530-6950
Blanchard Valley Medical Associates, Findlay, Ohio 45840, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
CCOP - Dayton, Dayton, Ohio 45429, United States; Recruiting
Howard M. Gross, MD, Phone: 937-395-8678
CCOP - Toledo Community Hospital, Toledo, Ohio 43617, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Charles F. Kettering Memorial Hospital, Kettering, Ohio 45429, United States; Recruiting
Clinical Trials Office - Charles F. Kettering Memorial Hospita, Phone: 937-298-3399 ext. 55506
David L. Rike Cancer Center at Miami Valley Hospital, Dayton, Ohio 45409, United States; Recruiting
Clinical Trials Office - David L. Rike Cancer Center, Phone: 937-208-2079
Firelands Regional Medical Center, Sandusky, Ohio 44870, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Flower Hospital Cancer Center, Sylvania, Ohio 43560, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Fremont Memorial Hospital, Fremont, Ohio 43420, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Fulton County Health Center, Wauseon, Ohio 43567, United States; Recruiting
Clinical Trials Office - Fulton County Health Center, Phone: 419-330-2708
Good Samaritan Hospital, Dayton, Ohio 45406, United States; Recruiting
Howard M. Gross, MD, Phone: 937-278-2612
Grandview Hospital, Dayton, Ohio 45405, United States; Recruiting
Howard M. Gross, MD, Phone: 937-226-3200
Kenton Oncology, Incorporated, Kenton, Ohio 43326, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Lima Memorial Hospital, Lima, Ohio 45804, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Medical University of Ohio Cancer Center, Toledo, Ohio 43614, United States; Recruiting
Clinical Trials Office - Medical University of Ohio Cancer Cen, Phone: 419-383-6583
Mercy Hospital of Tiffin, Tiffin, Ohio 44883, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Middletown Regional Hospital, Middletown, Ohio 45044, United States; Recruiting
Howard M. Gross, MD, Phone: 513-424-2111
North Coast Cancer Care, Incorporated, Sandusky, Ohio 44870, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Northwest Ohio Oncology Center, Maumee, Ohio 43537, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Ruth G. McMillan Cancer Center at Greene Memorial Hospital, Xenia, Ohio 45385, United States; Recruiting
Howard M. Gross, MD, Phone: 937-352-2140
Samaritan North Cancer Care Center, Dayton, Ohio 45415, United States; Recruiting
Howard M. Gross, MD, Phone: 937-279-5800
St. Charles Mercy Hospital, Oregon, Ohio 43616, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
St. Luke's Hospital, Maumee, Ohio 43537, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
St. Vincent Mercy Medical Center, Toledo, Ohio 43608, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Toledo Clinic - Oregon, Oregon, Ohio 43616, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Toledo Clinic, Incorporated - Main Clinic, Toledo, Ohio 43623, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Toledo Hospital, Toledo, Ohio 43606, United States; Recruiting
Clinical Trials Office - Toledo Hospital, Phone: 419-824-1842
United States Air Force Medical Center - Wright-Patterson, Wright-Patterson Afb, Ohio 45433-5529, United States; Recruiting
Sameh G. Abuerreish, MD, Phone: 937-257-1398
UVMC Cancer Care Center at Upper Valley Medical Center, Troy, Ohio 45373-1300, United States; Recruiting
Clinical Trials Office - UVMC Cancer Care Center, Phone: 937-440-4842
Veterans Affairs Medical Center - Dayton, Dayton, Ohio 45428, United States; Recruiting
Howard M. Gross, MD, Phone: 937-268-6511
Wood County Oncology Center, Bowling Green, Ohio 43402, United States; Recruiting
Paul L. Schaefer, MD, Phone: 419-843-6147
Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States; Recruiting
Jane Raymond, MD, Phone: 412-359-6147
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania 18711, United States; Recruiting
Clinical Trials Office - Frank M. and Dorothea Henry Cancer Ce, Phone: 570-271-5251
Geisinger Medical Center, Danville, Pennsylvania 17822-0001, United States; Recruiting
Clinical Trials Office - Geisinger Medical Center, Phone: 570-271-5251
Geisinger Medical Group - Scenery Park, State College, Pennsylvania 16801, United States; Recruiting
Albert M. Bernath, MD, Phone: 814-231-4560
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest, Allentown, Pennsylvania 18105, United States; Recruiting
Suresh G. Nair, MD, Phone: 610-402-0500
AnMed Health Cancer Center, Anderson, South Carolina 29621, United States; Recruiting
Clinical Trials Office - Rose Ramer Cancer Clinic, Phone: 864-261-2099
CCOP - Upstate Carolina, Spartanburg, South Carolina 29303, United States; Recruiting
Clinical Trials Office - CCOP - Upstate Carolina, Phone: 800-486-5941
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center, Spartanburg, South Carolina 29303, United States; Recruiting
Clinical Trials Office - Gibbs Regional Cancer Center, Phone: 800-486-5941
Avera Cancer Institute, Sioux Falls, South Dakota 57105, United States; Recruiting
Loren K. Tschetter, MD, Phone: 605-328-8000
Medical X-Ray Center, PC, Sioux Falls, South Dakota 57105, United States; Recruiting
Loren K. Tschetter, MD, Phone: 605-328-8000
Rapid City Regional Hospital, Rapid City, South Dakota 57701, United States; Recruiting
Richard C. Tenglin, Phone: 605-719-2360
Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls, South Dakota 57117-5039, United States; Recruiting
Clinical Trials Office - Sioux Valley Hospital and University, Phone: 605-328-1367
Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin 54143, United States; Recruiting
Anthony J. Jaslowski, MD, FACP, Phone: 920-884-3135
Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay, Wisconsin 54303, United States; Recruiting
Anthony J. Jaslowski, MD, FACP, Phone: 920-884-3135
Green Bay Oncology, Limited at St. Vincent Hospital, Green Bay, Wisconsin 54301-3526, United States; Recruiting
Anthony J. Jaslowski, MD, FACP, Phone: 920-884-3135
St. Mary's Hospital Medical Center - Green Bay, Green Bay, Wisconsin 54303, United States; Recruiting
Anthony J. Jaslowski, MD, FACP, Phone: 920-884-3135
St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin 54307-3508, United States; Recruiting
Clinical Trials Office - St. Vincent Hospital Regional Cancer, Phone: 920-433-8889
Welch Cancer Center at Sheridan Memorial Hospital, Sheridan, Wyoming 82801, United States; Recruiting
Patrick W. Cobb, MD, Phone: 307-674-6022

Additional Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Last updated: December 6, 2006

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